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1

Pharmacological inhibition of ULK1 kinase blocks mammalian target of rapamycin (mTOR)-dependent autophagy.

Petherick, Katy J., Conway, Owen J. L., Mpamhanga, Chido, Osborne, Simon A., Kamal, Ahmad, Saxty, Barbara, Ganley, Ian G.

Journal:

Journal of Biological Chemistry

Year:

2015

Language:

english

File:

PDF, 1.47 MB

english, 2015

2

Preparation of (±)-(erythro)-and (±)-(threo)-2-vinyl citric acids as potential mechanism-based inhibitors of ATP-citrate lyase

Roland E. Dolle, Riccardo Novelli, Barbara A. Saxty, Timothy N.C. Wells, Lawrence I. Kruse, Patrick Camilleri, Drake Eggleston

Journal:

Tetrahedron Letters

Year:

1991

Language:

english

File:

PDF, 174 KB

english, 1991

3

Inhibition of chemotaxis in A7r5 rat smooth muscle cells by a novel panel of inhibitors

B A Saxty, M Yadollahi-Farsani, P Kefalas, S Paul, J MacDermot

Journal:

British Journal of Pharmacology

Year:

1998

Language:

english

File:

PDF, 304 KB

english, 1998

4

Inactivation of platelet-derived growth factor-BB following modification by ADP-ribosyltransferase

Barbara A Saxty, Masoud Yadollahi-Farsani, Paul D Upton, Stephen R Johnstone, John MacDermot

Journal:

British Journal of Pharmacology

Year:

2001

Language:

english

File:

PDF, 211 KB

english, 2001

5

An intrinsically labile α-helix abutting the BCL9-binding site of β-catenin is required for its inhibition by carnosic acid

de la Roche, Marc, Rutherford, Trevor J., Gupta, Deepti, Veprintsev, Dmitry B., Saxty, Barbara, Freund, Stefan M., Bienz, Mariann

Journal:

Nature Communications

Year:

2012

Language:

english

File:

PDF, 1.08 MB

english, 2012

6

ChemInform Abstract: ATP-Citrate Lyase as a Target for Hypolipidemic Intervention. Design and Synthesis of 2-Substituted Butanedioic Acids as Novel, Potent Inhibitors of the Enzyme.

A. D. GRIBBLE, R. E. DOLLE, A. SHAW, D. MCNAIR, R. NOVELLI, C. E. NOVELLI, B. P. SLINGSBY, V. P. SHAH, D. TEW, B. A. SAXTY, M. ALLEN, P. H. GROOT, N. PEARCE, J. YATES

Journal:

Year:

1996

File:

PDF, 34 KB

1996

7

Substituted aminopyrimidine protein kinase B (PknB) inhibitors show activity against Mycobacterium tuberculosis

Timothy M. Chapman, Nathalie Bouloc, Roger S. Buxton, Jasveen Chugh, Kathryn E.A. Lougheed, Simon A. Osborne, Barbara Saxty, Stephen J. Smerdon, Debra L. Taylor, David Whalley

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 3.18 MB

english, 2012

8

Effective inhibitors of the essential kinase PknB and their potential as anti-mycobacterial agents

Kathryn E.A. Lougheed, Simon A. Osborne, Barbara Saxty, David Whalley, Tim Chapman, Nathalie Bouloc, Jasveen Chugh, Timothy J. Nott, Dony Patel, Vicky L. Spivey, Catherine A. Kettleborough, Justin S.

Journal:

Year:

2011

Language:

english

File:

PDF, 711 KB

english, 2011

9

Identification of a novel testis-specific primate antigen

L.E. Kerr, J.P. Brindle, B.A. Saxty, M. van Duin, R.J. Aitken

Journal:

Journal of Reproductive Immunology

Year:

1997

Language:

english

File:

PDF, 164 KB

english, 1997

10

Chemotaxin-dependent translocation of immunoreactive ADP-ribosyltransferase-1 to the surface of human neutrophil polymorphs

Panagiotis Kefalas, Barbara Saxty, Masoud Yadollahi-Farsani, John MacDermot

Journal:

Year:

1999

Language:

english

File:

PDF, 355 KB

english, 1999

11

Polymorphic forms of human ADP-ribosyltransferase-1 : Differences in their catalytic activities revealed by labeling of membrane-associated substrates

Masoud Yadollahi-Farsani, Panagiotis Kefalas, Barbara A. Saxty, John MacDermot

Journal:

Year:

1999

Language:

english

File:

PDF, 402 KB

english, 1999

12

Expression of protamine P2 in the testis of the common marmoset and man visualized using non-radioactive in-situ hybridization

P. T. K. SAUNDERS, J. GAUGHAN, B. A. SAXTY, L. E. KERR, M. R. MILLAR

Journal:

International Journal of Andrology

Year:

1996

Language:

english

File:

PDF, 1023 KB

english, 1996

13

Synthesis and evaluation of (+) and (−)-2,2-difluorocitrate as inhibitors of rat-liver ATP-citrate lyase and porcine-heart aconitase

Barbara A. SAXTY, Riccardo NOVELLI, Roland E. DOLLE, Lawrence I. KRUSE, David G. REID, Patrick CAMILLERI, Timothy N. C. WELLS

Journal:

Year:

1991

Language:

english

File:

PDF, 752 KB

english, 1991

14

Redox control of catalysis in ATP-citrate lyase from rat liver

Timothy N. C. WELLS, Barbara A. SAXTY

Journal:

Year:

1992

Language:

english

File:

PDF, 600 KB

english, 1992

15

Cloning and expression of a human ATP-citrate lyase cDNA

Nabil A. ELSHOURBAGY, Joseph C. NEAR, Peter J. KMETZ, Timothy N. C. WELLS, Pieter H. E. GROOT, Barbara A. SAXTY, Stephen A. HUGHES, Michelle FRANKLIN, Israel S. GLOGER

Journal:

Year:

1992

Language:

english

File:

PDF, 924 KB

english, 1992

16

117 Identification of novel cyclin dependent kinase 1/2 inhibitors using fragment based high-throughput X-ray crystallography and structure based drug design

P.G. Wyatt, V. Berdini, M.G. Carr, J.E. Curry, D.J. Davis, M. O'Reilly, G. Saxty, M.S. Squires, A.J. Woodhead, A.J.-A. Woolford

Journal:

European Journal of Cancer Supplements

Year:

2004

Language:

english

File:

PDF, 126 KB

english, 2004

17

332 Fragment-based and structure based optimisation of potent PKB/AKT inhibitors

P. Wyatt, D. Barford, T. Davies, S. Woodhead, G. Saxty, D. Davis, M. Garrett, F. Raynaud, S. Eccles, V. Berdini

Journal:

European Journal of Cancer Supplements

Year:

2004

Language:

english

File:

PDF, 149 KB

english, 2004

18

ATP-Citrate Lyase as a Target for Hypolipidemic Intervention. Design and Synthesis of 2-Substituted Butanedioic Acids as Novel, Potent Inhibitors of the Enzyme

Gribble, Andrew D., Dolle, Roland E., Shaw, Antony, McNair, David, Novelli, Riccardo, Novelli, Christine E., Slingsby, Brian P., Shah, Virendra P., Tew, David, Saxty, Barbara A., Allen, Mark, Groot, P

Journal:

Journal of Medicinal Chemistry

Year:

1996

Language:

english

File:

PDF, 832 KB

english, 1996

19

Identification of Inhibitors of Protein Kinase B Using Fragment-Based Lead Discovery †

Saxty, Gordon, Woodhead, Steven J., Berdini, Valerio, Davies, Thomas G., Verdonk, Marcel L., Wyatt, Paul G., Boyle, Robert G., Barford, David, Downham, Robert, Garrett, Michelle D., Carr, Robin A.

Journal:

Journal of Medicinal Chemistry

Year:

2007

Language:

english

File:

PDF, 278 KB

english, 2007

20

A Casein kinase 1/Checkpoint kinase 1 pyrazolo-pyridine protein kinase inhibitor as novel activator of the p53 pathway

Huart, Anne-Sophie, Saxty, Barbara, Merritt, Andy, Nekulova, Marta, Lewis, Stephen, Huang, Yide, Vojtesek, Borivoj, Kettleborough, Catherine, Hupp, Ted R.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 2.00 MB

english, 2013

21

ATP-citrate-lyase as a target for hypolipidemic intervention. Sulfoximine and 3-hydroxy-.beta.-lactam containing analogs of citric acid as potential tight-binding inhibitors

Dolle, Roland E., McNair, David, Hughes, Mark J., Kruse, Lawrence I., Eggelston, Drake, Saxty, Barbara A., Wells, Timothy N. C., Groot, Pieter H. E.

Journal:

Journal of Medicinal Chemistry

Year:

1992

Language:

english

File:

PDF, 1.32 MB

english, 1992

22

Discovery of Plasmodium vivax N -Myristoyltransferase Inhibitors: Screening, Synthesis, and Structural Characterization of their Binding Mode

Goncalves, Victor, Brannigan, James A., Whalley, David, Ansell, Keith H., Saxty, Barbara, Holder, Anthony A., Wilkinson, Anthony J., Tate, Edward W., Leatherbarrow, Robin J.

Journal:

Journal of Medicinal Chemistry

Year:

2012

Language:

english

File:

PDF, 2.64 MB

english, 2012

23

Synthesis of Novel Thiol-Containing Citric Acid Analogs. Kinetic Evaluation of These and Other Potential Active-Site-Directed and Mechanism-Based Inhibitors of ATP Citrate Lyase

Dolle, Roland E., Gribble, Andy, Wilkes, Tracey, Kruse, Lawrence I., Eggleston, Drake, Saxty, Barbara A., Wells, Timothy N. C., Groot, Pieter H. E.

Journal:

Journal of Medicinal Chemistry

Year:

1995

Language:

english

File:

PDF, 904 KB

english, 1995

24

356 Discovery of novel pyrido[2,3-b]pyrazine as fibroblast growth factor receptor (FGFR-1, 2, 3 & 4) kinase inhibitors with nanomolar affinity

Angibaud, P., Querolle, O., Berdini, V., Saxty, G., Cleasby, A., Colombel, H., Csoka, I., Gilissen, R., King, P., Meerpoel, L., Paulussen, C., Pilatte, I., Poncelet, V., Rees, D.C., Roux, B., Tronel,

Journal:

European Journal of Cancer

Year:

2014

Language:

english

File:

PDF, 58 KB

english, 2014

25

400 Optimization of novel pyrido[2,3-b]pyrazine based small molecule fibroblast growth factor receptor 1, 2, 3 & 4 (FGFR) inhibitors into a potential clinical candidate

Angibaud, P., Querolle, O., Berdini, V., Saxty, G., Cleasby, A., Colombel, H., Csoka, I., Esser, N., Gilissen, R., Meerpoel, L., Paulussen, C., Pilatte, I., Poncelet, V., Rees, D.C., Roux, B., Verhuls

Journal:

European Journal of Cancer

Year:

2014

Language:

english

File:

PDF, 58 KB

english, 2014

26

Antitubercular specific activity of ibuprofen and the other 2-arylpropanoic acids using the HT-SPOTi whole-cell phenotypic assay

Guzman, J. D., Evangelopoulos, D., Gupta, A., Birchall, K., Mwaigwisya, S., Saxty, B., McHugh, T. D., Gibbons, S., Malkinson, J., Bhakta, S.

Journal:

Year:

2013

Language:

english

File:

PDF, 1.36 MB

english, 2013

27

A High-Throughput Assay for Modulators of NNT Activity in Permeabilized Yeast Cells

Meadows, N. A., Saxty, B., Albury, M. S., Kettleborough, C. A., Ashcroft, F. M., Moore, A. L., Cox, R. D.

Journal:

Journal of Biomolecular Screening

Year:

2011

Language:

english

File:

PDF, 361 KB

english, 2011

28

Group Cognitive Behavioural Therapy for Chronic Fatigue Syndrome: A Pilot Study

Saxty, Maxwell, Hansen, Zara

Journal:

Behavioural and Cognitive Psychotherapy

Year:

2005

Language:

english

File:

PDF, 59 KB

english, 2005

29

Potent, Selective Inhibitors of Fibroblast Growth Factor Receptor Define Fibroblast Growth Factor Dependence in Preclinical Cancer Models

Squires, M., Ward, G., Saxty, G., Berdini, V., Cleasby, A., King, P., Angibaud, P., Perera, T., Fazal, L., Ross, D., Jones, C. G., Madin, A., Benning, R. K., Vickerstaffe, E., O'Brien, A., Frederickso

Journal:

Molecular Cancer Therapeutics

Year:

2011

Language:

english

File:

PDF, 3.70 MB

english, 2011

30

Identification of Small-Molecule Inhibitors of the Ribonuclease H2 Enzyme

White, R., Saxty, B., Large, J., Kettleborough, C. A., Jackson, A. P.

Journal:

Journal of Biomolecular Screening

Year:

2013

Language:

english

File:

PDF, 1.83 MB

english, 2013

31

Pharmacological Inhibition of ULK1 Kinase Blocks Mammalian Target of Rapamycin (mTOR)-dependent Autophagy

Petherick, Katy J., Conway, Owen J. L., Mpamhanga, Chido, Osborne, Simon A., Kamal, Ahmad, Saxty, Barbara, Ganley, Ian G.

Journal:

Journal of Biological Chemistry

Year:

2015

Language:

english

File:

PDF, 3.03 MB

english, 2015

32

N-Hydroxyimides and hydroxypyrimidinones as inhibitors of the DNA repair complex ERCC1–XPF

T. M. Chapman, C. Wallace, K. J. Gillen, P. Bakrania, P. Khurana, P. J. Coombs, S. Fox, E. A. Bureau, J. Brownlees, D. W. Melton, B. Saxty

Year:

2015

Language:

english

File:

PDF, 2.96 MB

english, 2015

33

Catechols and 3-hydroxypyridones as inhibitors of the DNA repair complex ERCC1-XPF

T. M. Chapman, K. J. Gillen, C. Wallace, M. T. Lee, P. Bakrania, P. Khurana, P. J. Coombs, L. Stennett, S. Fox, E. A. Bureau, J. Brownlees, D. W. Melton, B. Saxty

Year:

2015

Language:

english

File:

PDF, 3.78 MB

english, 2015

34

Mono-acidic inhibitors of the Kelch-like ECH-associated protein 1 : Nuclear factor erythroid 2–related factor 2 (KEAP1:NRF2) protein-protein interaction with high cell potency identified by Fragment-based Discovery

Davies, Thomas G., Wixted, William E, Coyle, Joseph E., Griffiths-Jones, Charlotte, Hearn, Keisha, McMenamin, Rachel L., Norton, David, Rich, Sharna J., Richardson, Caroline, Saxty, Gordon, Willems, H

Journal:

Journal of Medicinal Chemistry

Year:

2016

Language:

english

File:

PDF, 2.15 MB

english, 2016

35

Sperm surface antigens and the prospects for contraceptive vaccine development

Saxty, Barbara, Aitken, John

Journal:

Reproductive Medicine Review

Year:

1997

Language:

english

File:

PDF, 1.47 MB

english, 1997

36

Remission and relapse in major depression: a two-year prospective follow-up study

Ramana, R., Paykel, E. S., Cooper, Z., Hayhurst, H., Saxty, M., Surtees, P. G.

Journal:

Psychological Medicine

Year:

1995

Language:

english

File:

PDF, 823 KB

english, 1995

37

ENDOCRINE AND EMOTIONAL EFFECTS OF NALOXONE (1mg/kg) IN DEPRESSED PATIENTS AND HEALTHY CONTROLS

Barocka, A., Paykel, E., Herbert, J., Grossman, A., Gibson-Saxty, J.

Journal:

Clinical Neuropharmacology

Year:

1992

File:

PDF, 520 KB

1992

38

96 Stable expression for investigation of possible differential activity of two polymorphic forms of the human arginine specific ADP-ribosyltransferase

YADOLLAHI-FARSANI, MASOUD, KEFALAS, PANAGIOTIS, SAXTY, BARBARA A., MACDERMOT, JOHN

Journal:

Biochemical Society Transactions

Year:

1998

Language:

english

File:

PDF, 96 KB

english, 1998

39

The purification of a cysteine-dependent NAD + glycohydrolase activity from bovine erythrocytes and evidence that it exhibits a novel ADP-ribosyltransferase activity

Saxty, B A, van Heyningen, S

Journal:

Biochemical Journal

Year:

1995

Language:

english

File:

PDF, 1.60 MB

english, 1995

40

97 Arginine-specific ADP-ribosyltransferase of human polymorphonuclear neutrophil leucocytes: cDNA cloning and identification of a polymorphic site in the coding region

KEFALAS, Panagiotis, YADOLLAHI-FARSANI, Masoud, SAXTY, Barbara A., MACDERMOT, John

Journal:

Biochemical Society Transactions

Year:

1998

Language:

english

File:

PDF, 151 KB

english, 1998

41

ADP-ribosyltransferase inhibitors and pseudo-substrates inhibit rat smooth muscle cell migration in vitro

Saxty, Barbara, Yadollahi-Farsani, Masoud, Kefalas, Panagiotis, Paul, Surekha, MacDermot, John

Journal:

Biochemical Society Transactions

Year:

1998

Language:

english

File:

PDF, 104 KB

english, 1998

42

Cell surface ADP-ribosyltransferase attenuates PDGF-BB dependent proliferation of cells

Saxty, B. A., Johnstone, S. R., Yadollahi-Farsani, M., Macdermot, J.

Journal:

Biochemical Society Transactions

Year:

2000

Language:

english

File:

PDF, 148 KB

english, 2000

43

ADP-Ribosyltransferase-1 and Leucocyte Chemotaxis

MacDermot, J, Kefalas, P, Yadollahi-Farsani, M, Saxty, BA

Journal:

Clinical Science

Year:

1999

Language:

english

File:

PDF, 158 KB

english, 1999

44

Arginine-specific ADP-ribosyltransferases in leukocytes

Saxty, Barbara A., Kefalas, Panagiotis, Yadollahi-Farsani, Masoud, MacDermot, John

Journal:

Journal of Leukocyte Biology

Year:

1998

Language:

english

File:

PDF, 73 KB

english, 1998

45

A nurse-led model at public academic hospitals maintains high adherence to colorectal cancer surveillance guidelines

Symonds, Erin L, Simpson, Kalindra, Coats, Michelle, Chaplin, Angela, Saxty, Karen, Sandford, Jayne, Young AM, Graeme P, Cock, Charles, Fraser, Robert, Bampton, Peter A

Journal:

The Medical Journal of Australia

Year:

2018

Language:

english

File:

PDF, 171 KB

english, 2018

46

Some Experiments with Suggestion and Association Tests in the Feeble-Minded

Journal:

The British Journal of Psychiatry

Year:

1930

Language:

english

File:

PDF, 919 KB

english, 1930

47

Design of the LifeArc Index Set and Retrospective Review of Its Performance: A Collection for Sharing

Birchall, Kristian, Merritt, Andy, Sattikar, Afrah, Kettleborough, Catherine, Saxty, Barbara

Journal:

Year:

2018

Language:

english

File:

PDF, 951 KB

english, 2018

48

PROGRESS TO ALUMINIUM-LITHIUM SEMI-FABRICATED PRODUCTS

GRIMES, R., DAVIS, T., SAXTY, H. J., FEARON, J. E.

Journal:

Le Journal de Physique Colloques

Year:

1987

Language:

english

File:

PDF, 413 KB

english, 1987

49

PROGRESS TO ALUMINIUM-LITHIUM SEMI-FABRICATED PRODUCTS

GRIMES, R., DAVIS, T., SAXTY, H. J., FEARON, J. E.

Journal:

Le Journal de Physique Colloques

Year:

1987

File:

PDF, 413 KB

1987

50

P-130. Identification of novel sperm antigens with potential as immunocontraceptives

Kerr, L.E., Brindle, J.P., Saxty, B.A., van Duin, M., Aitken, R.J.

Journal:

Human Reproduction

Year:

1997

Language:

english

File:

PDF, 326 KB

english, 1997